Prenatal Exposure to Retrorsine Induces Developmental Toxicity and Hepatotoxicity of Fetal Rats in a Sex-Dependent Manner: The Role of Pregnane X Receptor Activation

Author:

Dai Yongguo12ORCID,Luo Jinyuan3,Xiang E12,Guo Qi12,He Zheng4,Gong Zheng12ORCID,Sun Xiaoxiang12ORCID,Kou Hao25,Xu Kequan12,Fan Chengpeng6,Liu Jie12,Qiu Shuaikai12,Wang Yanqing7,Wang Hui12ORCID,Guo Yu12ORCID

Affiliation:

1. Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071 Hubei Province, China

2. Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, 430071 Hubei Province, China

3. Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, 430060 Hubei Province, China

4. Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China

5. Department of Pharmacy, Zhongnan Hospital of Wuhan University, Wuhan, 430071 Hubei Province, China

6. Department of Biochemistry and Molecular Biology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071 Hubei Province, China

7. Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060 Hubei Province, China

Funder

Wuhan University

National Natural Science Foundation of China

Hubei Province

School of Medicine, Wuhan University

Publisher

American Chemical Society (ACS)

Subject

General Agricultural and Biological Sciences,General Chemistry

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