Isolation, Structure, Absolute Stereochemistry, and HIV-1 Integrase Inhibitory Activity of Integrasone, a Novel Fungal Polyketide-Reference-Cited by-同舟云学术

Isolation, Structure, Absolute Stereochemistry, and HIV-1 Integrase Inhibitory Activity of Integrasone, a Novel Fungal Polyketide

Published:2004-03-18 Issue:5 Volume:67 Page:872-874
ISSN:0163-3864
Container-title:Journal of Natural Products
language:en
Short-container-title:J. Nat. Prod.

Author:

Herath Kithsiri B.¹,Jayasuriya Hiranthi¹,Bills Gerald F.¹,Polishook Jon D.¹,Dombrowski Anne W.¹,Guan Ziqiang¹,Felock Peter J.¹,Hazuda Daria J.¹,Singh Sheo B.¹

Affiliation:

1. Natural Products Chemistry, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, CIBE, Merck Sharp & Dohme de Espana, S. A. Josefa Valcárcel 38, 28027 Madrid, Spain, and Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania 19486

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/np0340504

Reference15 articles.

1. HIV Integrase, a Brief Overview from Chemistry to Therapeutics

2. Patented small molecule inhibitors of HIV-1 integrase: a 10-year saga

3. Dipyrimidine-based inhibitors of HIV-1 integrase

4. Inhibitors of Strand Transfer That Prevent Integration and Inhibit HIV-1 Replication in Cells

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