hERG Classification Model Based on a Combination of Support Vector Machine Method and GRIND Descriptors-Reference-Cited by-同舟云学术

hERG Classification Model Based on a Combination of Support Vector Machine Method and GRIND Descriptors

Published:2008-01-16 Issue:1 Volume:5 Page:117-127
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Li Qiyuan¹,Jørgensen Flemming Steen¹,Oprea Tudor¹,Brunak Søren¹,Taboureau Olivier¹

Affiliation:

1. Center for Biological Sequence Analysis, Biocentrum-DTU, Technical University of Denmark, Building 208, DK-2800 Lyngby, Denmark, Department of Medicinal Chemistry, The Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark, and Division of Biocomputing, Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, MSC11 6145, Albuquerque, New Mexico 87131

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp700124e

Reference67 articles.

1. Drugs, hERG and sudden death

2. Understanding the Structure−Activity Relationship of the Human Ether-a-go-go-Related Gene Cardiac K+ Channel. A Model for Bad Behavior

3. Safety of Non-Antiarrhythmic Drugs that Prolong the QT Interval or Induce Torsade de Pointes

4. QT-interval prolongation by non-cardiac drugs: lessons to be learned from recent experience

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