Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors-Reference-Cited by-同舟云学术

Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors

Published:2014-11-26 Issue:23 Volume:57 Page:10072-10079
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Flanagan Mark E.¹,Abramite Joseph A.¹,Anderson Dennis P.¹,Aulabaugh Ann¹,Dahal Upendra P.¹,Gilbert Adam M.¹,Li Chao¹,Montgomery Justin¹,Oppenheimer Stacey R.¹,Ryder Tim¹,Schuff Brandon P.¹,Uccello Daniel P.¹,Walker Gregory S.¹,Wu Yan¹,Brown Matthew F.¹,Chen Jinshan M.¹,Hayward Matthew M.¹,Noe Mark C.¹,Obach R. Scott¹,Philippe Laurence¹,Shanmugasundaram Veerabahu¹,Shapiro Michael J.¹,Starr Jeremy¹,Stroh Justin¹,Che Ye¹

Affiliation:

1. Center of Chemistry Innovation and Excellence, and ‡Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Eastern Point Road, Groton, Connecticut 06340, United States

Funder

Pfizer

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm501412a

Reference40 articles.

1. The resurgence of covalent drugs

2. Drug discovery for a new generation of covalent drugs

3. Covalent Modifiers: An Orthogonal Approach to Drug Design

4. Strategies for discovering and derisking covalent, irreversible enzyme inhibitors

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