Generation of Ligand-Based Pharmacophore Model and Virtual Screening for Identification of Novel Tubulin Inhibitors with Potent Anticancer Activity-Reference-Cited by-同舟云学术

Generation of Ligand-Based Pharmacophore Model and Virtual Screening for Identification of Novel Tubulin Inhibitors with Potent Anticancer Activity

Published:2009-06-09 Issue:14 Volume:52 Page:4221-4233
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chiang Yi-Kun¹²,Kuo Ching-Chuan³,Wu Yu-Shan⁴,Chen Chung-Tong²,Coumar Mohane Selvaraj²,Wu Jian-Sung²,Hsieh Hsing-Pang²,Chang Chi-Yen³,Jseng Huan-Yi²,Wu Ming-Hsine²,Leou Jiun-Shyang²,Song Jen-Shin²,Chang Jang-Yang³,Lyu Ping-Chiang¹,Chao Yu-Sheng²,Wu Su-Ying²

Affiliation:

1. Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 300, Taiwan, Republic of China

2. Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan, Republic of China

3. National Institute of Cancer Research, National Health Research Institutes, Tainan 704, Taiwan, Republic of China

4. Department of Chemistry, Tunghai University, 181 Taichung Harbor Road Sec. 3, Taichung 407, Taiwan, Republic of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801649y

Reference32 articles.

1. Microtubule dynamics

2. Drug target interaction of tubulin-binding drugs in cancer therapy

3. New tubulin targeting agents currently in clinical development

4. Mechanisms of Action of and Resistance to Antitubulin Agents: Microtubule Dynamics, Drug Transport, and Cell Death

5. Highly Potent Triazole-Based Tubulin Polymerization Inhibitors

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