Exploring the antitumor potential of novel quinoline derivatives via tubulin polymerization inhibition in breast cancer; design, synthesis and molecular docking

Author:

Abdelmegeed Heba1,Abdel Ghany Lina M. A.2ORCID,Youssef Amira3,El-Etrawy Abd-Allah S.34,Ryad Noha3

Affiliation:

1. Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Giza 12622, Egypt

2. Pharmaceutical Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MUST), 6th of October City, P.O. Box 77, Giza, Egypt

3. Pharmaceutical Organic Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MUST), 6th of October City, P.O. Box 77, Giza, Egypt

4. Department of Chemistry, Basic Science, Misr University for Science and Technology (MUST), 6th of October City, P.O. Box 77, Giza, Egypt

Abstract

A series of quinoline derivatives was designed and synthesized as novel tubulin inhibitors targeting the colchicine binding site.

Publisher

Royal Society of Chemistry (RSC)

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