4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]- piperazinyl]-6,7-dimethoxyquinazoline (L-765,314): A Potent and Selective α1b Adrenergic Receptor Antagonist-Reference-Cited by-同舟云学术

4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]- piperazinyl]-6,7-dimethoxyquinazoline (L-765,314): A Potent and Selective α1b Adrenergic Receptor Antagonist

Published:1998-03-19 Issue:8 Volume:41 Page:1205-1208
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Patane Michael A.¹,Scott Ann L.¹,Broten Theodore P.¹,Chang Raymond S. L.¹,Ransom Richard W.¹,DiSalvo Jerry¹,Forray Carlos¹,Bock Mark G.¹

Affiliation:

1. Departments of Medicinal Chemistry, Cardiovascular Pharmacology, and New Lead Pharmacology, Merck & Co., Inc., West Point, Pennsylvania 19486, Biochemistry and Physiology Department, Merck & Co., Inc., Rahway, New Jersey 07065, and Synaptic Pharmaceutical Corp., 215 College Road, Paramus, New Jersey 07652

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980053f

Reference19 articles.

1. Blockade of the Flush Associated with Metastatic Gastric Carcinoid by Combined Histamine H1and H2Receptor Antagonists

2. Adrenergic and Cholinergic Receptors in the Human Prostate, Prostatic Capsule and Bladder Neck

3. Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype.

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