Structure Guided Design and Kinetic Analysis of Highly Potent Benzimidazole Inhibitors Targeting the PDEδ Prenyl Binding Site-Reference-Cited by-同舟云学术

Structure Guided Design and Kinetic Analysis of Highly Potent Benzimidazole Inhibitors Targeting the PDEδ Prenyl Binding Site

Published:2014-06-11 Issue:12 Volume:57 Page:5435-5448
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zimmermann Gunther¹²,Schultz-Fademrecht Carsten³,Küchler Philipp¹²,Murarka Sandip¹,Ismail Shehab¹⁴,Triola Gemma¹⁵,Nussbaumer Peter³,Wittinghofer Alfred¹,Waldmann Herbert¹²

Affiliation:

1. Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany

2. Department of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany

3. Lead Discovery Center, Otto-Hahn-Strasse 15, 44227 Dortmund, Germany

4. The Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom

5. Institute of Advanced Chemistry of Catalonia (IQAC), Spanish National Research Council (CSIC), Jordi Girona, 18-26, 08034 Barcelona, Spain

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500632s

Reference35 articles.

1. Lipidated Ras and Rab Peptides and Proteins—Synthesis, Structure, and Function

2. Ras trafficking, localization and compartmentalized signalling

3. The Ras superfamily at a glance

4. Ras inhibition via direct Ras binding—is there a path forward?

5. Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

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