Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery-Reference-Cited by-同舟云学术

Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery

Published:2007-04-24 Issue:10 Volume:50 Page:2293-2296
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Saxty Gordon¹,Woodhead Steven J.¹,Berdini Valerio¹,Davies Thomas G.¹,Verdonk Marcel L.¹,Wyatt Paul G.¹,Boyle Robert G.¹,Barford David¹,Downham Robert¹,Garrett Michelle D.¹,Carr Robin A.¹

Affiliation:

1. Astex Therapeutics Ltd., 436 Cambridge Science Park, Milton Road, Cambridge, CB4 0QA, United Kingdom, Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, United Kingdom, and Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm070091b

Reference24 articles.

1. Advances in protein kinase B signalling: AKTion on multiple fronts☆

2. The Akt/PKB Family of Protein Kinases: A Review of Small Molecule Inhibitors and Progress Towards Target Validation

3. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

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