2,7-Disubstituted-pyrrolo[2,1-f][1,2,4]triazines: New Variant of an Old Template and Application to the Discovery of Anaplastic Lymphoma Kinase (ALK) Inhibitors with in Vivo Antitumor Activity-Reference-Cited by-同舟云学术

2,7-Disubstituted-pyrrolo[2,1-f][1,2,4]triazines: New Variant of an Old Template and Application to the Discovery of Anaplastic Lymphoma Kinase (ALK) Inhibitors with in Vivo Antitumor Activity

Published:2011-08-22 Issue:18 Volume:54 Page:6328-6341
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ott Gregory R.¹,Wells Gregory J.¹,Thieu Tho V.¹,Quail Matthew R.¹,Lisko Joseph G.¹,Mesaros Eugen F.¹,Gingrich Diane E.¹,Ghose Arup K.¹,Wan Weihua¹,Lu Lihui¹,Cheng Mangeng¹,Albom Mark S.¹,Angeles Thelma S.¹,Huang Zeqi¹,Aimone Lisa D.¹,Ator Mark A.¹,Ruggeri Bruce A.¹,Dorsey Bruce D.¹

Affiliation:

1. Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, Pennsylvania 19380, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200758k

Reference49 articles.

1. Mechanisms that Promote and Suppress Chromosomal Translocations in Lymphocytes

2. Imatinib as a Paradigm of Targeted Therapies

3. The development of imatinib as a therapeutic agent for chronic myeloid leukemia