Role of Hydrophobic Substituents on the Terminal Nitrogen of Histamine in Receptor Binding and Agonist Activity: Development of an Orally Active Histamine Type 3 Receptor Agonist and Evaluation of Its Antistress Activity in Mice-Reference-Cited by-同舟云学术

Role of Hydrophobic Substituents on the Terminal Nitrogen of Histamine in Receptor Binding and Agonist Activity: Development of an Orally Active Histamine Type 3 Receptor Agonist and Evaluation of Its Antistress Activity in Mice

Published:2010-04-12 Issue:9 Volume:53 Page:3840-3844
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ishikawa Makoto¹,Shinei Rie¹,Yokoyama Fumikazu¹,Yamauchi Miki¹,Oyama Masayo¹,Okuma Kunihiro¹,Nagayama Takako¹,Kato Kazuhiko¹,Kakui Nobukazu¹,Sato Yasuo¹

Affiliation:

1. Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901890s

Reference37 articles.

1. Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor

2. Histamine H3-receptor activation inhibits acetylcholine release from the guinea pig myenteric plexus

3. Is monoamine turnover in the brain regulated by histamine H3 receptors?