Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil and N-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease-Reference-Cited by-同舟云学术

Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil and N-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease

Published:2011-11-15 Issue:24 Volume:54 Page:8251-8270
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bolea Irene¹,Juárez-Jiménez Jordi²,de los Rı́os Cristóbal³,Chioua Mourad⁴,Pouplana Ramón²,Luque F. Javier²,Unzeta Mercedes¹,Marco-Contelles José⁴,Samadi Abdelouahid⁴

Affiliation:

1. Departament de Bioquı́mica i Biologı́a Molecular, Facultat de Medicina, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain

2. Departament de Fisicoquı́mica, Facultat de Farmàcia, and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Diagonal 643, E-08028, Barcelona, Spain

3. Instituto Teófilo Hernando, Fundación de Investigación Biomédica, Hospital Universitario de la Princesa, C/Diego de León, 62, E-28029, Madrid, Spain

4. Laboratorio de Radicales Libres y Quı́mica Computacional (IQOG, CSIC), Juan de la Cierva 3, E-28006, Madrid, Spain

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200853t

Reference97 articles.

1. A Century of Alzheimer's Disease

2. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

3. Oxidative Stress, Glutamate, and Neurodegenerative Disorders

4. Oxidative stress in Alzheimer disease

Cited by 210 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Some heterocycles connected to substituted piperazine by 1,3,4-oxadiazole linker: Design, synthesis, anticholinesterase and antioxidant activity;Journal of Molecular Structure;2025-02

2. N‐Benzyl piperidine Fragment in Drug Discovery;ChemMedChem;2024-08-23

3. In vitro and in vivo Biological Evaluation of Newly Tacrine-Selegiline Hybrids as Multi-Target Inhibitors of Cholinesterases and Monoamine Oxidases for Alzheimer’s Disease;Drug Design, Development and Therapy;2024-01

4. Design, Synthesis, Anticholinesterase and Antioxidant Activity of Indole, Benzothiophene and Thiophen-Based 1,3,4-Oxadiazole Derivatives;2024

5. Piperidine: A Versatile Heterocyclic Ring for Developing Monoamine Oxidase Inhibitors;ACS Omega;2023-10-03