Affiliation:
1. M.M College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, India
2. Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India
3. Laureate Institute of Pharmacy, Kangra,
H.P, India
Abstract
Abstract:
1,3-thiazoles, which contain nitrogen and a sulfur atom is an unsaturated five-membered
heterocyclic ring, have achieved a unique significant place in drug design and development because
of their versatile structure and a variety of pharmacological activities, viz. anticancer, antiviral,
antimicrobial, anticonvulsant, antioxidant, antidiabetic, etc. They have inspired researchers to
design novel thiazole with different biological activities. The presence of the thiazole moiety has resulted
in a large number of clinically useful drugs with a wide range of activities, such as Ritonavir
(antiviral), Sulfathiazole (antimicrobial antibiotic), Abafungin, Ravuconazole (antifungal), Meloxicam
(NSAID), etc., that further verify this statement. The prevalence of neurodegenerative diseases
like Alzheimer's, Parkinson's, and Huntington’s is increasing at a rapid pace but existing treatments
mainly provide symptomatic relief and are associated with undesired effects. Consequently, designing
novel compounds with more effectiveness and reduced toxicity are required. 1,3-thiazole derivatives
have emerged as excellent candidate in this regard and have an important role for the treatment
of neurodegenerative diseases. In the current review, we have gathered all the appropriate literature
which demonstrate the remarkable role of 1,3-thiazole and its derivatives in these diseases
that may help design new compounds with more desired characteristics. The literature was assessed
through worldwide scientific databases like GOOGLE, SCOPUS, and PUBMED using different
keywords, and only relevant information published in English was evaluated.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
Cited by
2 articles.
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