Evidence for Metabolic Cleavage of a PEGylated Protein in Vivo Using Multiple Analytical Methodologies-Reference-Cited by-同舟云学术

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Evidence for Metabolic Cleavage of a PEGylated Protein in Vivo Using Multiple Analytical Methodologies

Published:2012-04-18 Issue:5 Volume:9 Page:1291-1301
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Elliott Victoria L.¹,Edge George T.¹,Phelan Marie M.²,Lian Lu-Yun²,Webster Rob³,Finn Rory F.⁴,Park B. Kevin¹,Kitteringham Neil R.¹

Affiliation:

1. MRC Centre for Drug Safety Science, Department of Pharmacology & Therapeutics, University of Liverpool, Liverpool, United Kingdom

2. Liverpool NMR Centre for Structural Biology, University of Liverpool, Liverpool, United Kingdom

3. Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Sandwich, United Kingdom

4. BioTech, Pfizer Global Research and Development, St. Louis, Missouri, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp200587m

Reference36 articles.

1. Effect of pegylation on pharmaceuticals

2. Emerging PEGylated drugs

3. Pegylation for improving the effectiveness of therapeutic biomolecules

4. Peptide and protein PEGylation III: advances in chemistry and clinical applications

5. In Vivo Pharmacology and Toxicology Evaluation of Polyethylene Glycol-Conjugated Interferon β-1a

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