Minimizing Drug Exposure in the CNS while Maintaining Good Oral Absorption
Author:
Affiliation:
1. Pfizer Neusentis, Portway Building, Granta Park, Great Abington, Cambridge CB21 6GS, United Kingdom
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ml300378n
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1. P-Glycoprotein Limits the Brain Penetration of Nonsedating but not Sedating H1-Antagonists
2. A comprehensive non-clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder
3. The influence of drug-like concepts on decision-making in medicinal chemistry
4. Estimation of Blood-Brain Barrier Crossing of Drugs Using Molecular Size and Shape, and H-Bonding Descriptors
5. Full efficacy with no CNS side-effects: unachievable panacea or reality? DMPK considerations in design of drugs with limited brain penetration
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