Discovery of Arylsulfonamide Nav1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile-Reference-Cited by-同舟云学术

Discovery of Arylsulfonamide Nav1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile

Published:2021-06-01 Issue:6 Volume:12 Page:1038-1049
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Roecker Anthony J.¹^ORCID,Layton Mark E.¹,Pero Joseph E.¹^ORCID,Kelly Michael J.¹,Greshock Thomas J.¹^ORCID,Kraus Richard L.²,Li Yuxing²,Klein Rebecca²,Clements Michelle²,Daley Christopher²,Jovanovska Aneta²,Ballard Jeanine E.³,Wang Deping⁴,Zhao Fuqiang⁵,Brunskill Andrew P. J.⁶,Peng Xuanjia⁷^ORCID,Wang Xiu⁸,Sun Haiyan⁸,Houghton Andrea K.²,Burgey Christopher S.¹

Affiliation:

1. Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

2. Pharmacology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

3. Pharmacokinetic, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

4. Computational and Structural Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

5. Translational Imaging and Biomarkers, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

6. Molecular and Materials Characterization, Merck & Co., Inc., Rahway, New Jersey 07065, United States

7. HitS Unite, WuXi AppTec Co., Ltd. (Shanghai), Shanghai 200131, China

8. IDSU, WuXi AppTec Co., Ltd. (Shanghai), Shanghai 200131, China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00218

Reference41 articles.

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