Structure-Based Discovery of Nonpeptidic Small Organic Compounds To Block the T Cell Response to Myelin Basic Protein-Reference-Cited by-同舟云学术

Structure-Based Discovery of Nonpeptidic Small Organic Compounds To Block the T Cell Response to Myelin Basic Protein

Published:2004-09-03 Issue:21 Volume:47 Page:4989-4997
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Koehler Niklas K. U.¹,Yang Chao-Yie¹,Varady Judith¹,Lu Yipin¹,Wu ¹,Liu Ming¹,Yin Daxu¹,Bartels Margreet¹,Xu Bi-ying¹,Roller Peter P.¹,Long Ya-qiu¹,Li Peng¹,Kattah Michael¹,Cohn Marjorie L.¹,Moran Kelly¹,Tilley Eurona¹,Richert John R.¹,Wang Shaomeng¹

Affiliation:

1. Departments of Microbiology and Immunology, Neurology, and Pathology, Georgetown University Medical Center, Washington, D.C. 20007, Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109-0934, and Laboratory of Medicinal Chemistry, National Cancer Institute, National Institutes of Health, Frederick, Maryland 20892

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030362s

Reference41 articles.

1. Immunological Aspects of Demyelinating Diseases

2. Heterogeneity of the T-cell receptor ? gene rearrangements generated in myelin basic protein-specific T-cell clones isolated from a patient with multiple sclerosis

3. T cell response to myelin basic protein in the context of the multiple sclerosis-associated HLA-DR15 haplotype: peptide binding, immunodominance and effector functions of T cells

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