Real-Time Biological Annotation of Synthetic Compounds-Reference-Cited by-同舟云学术

Real-Time Biological Annotation of Synthetic Compounds

Published:2016-07-11 Issue:28 Volume:138 Page:8920-8927
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Gerry Christopher J.¹,Hua Bruce K.¹,Wawer Mathias J.,Knowles Jonathan P.²,Nelson Jr. Shawn D.¹,Verho Oscar¹,Dandapani Sivaraman,Wagner Bridget K.,Clemons Paul A.,Booker-Milburn Kevin I.²,Boskovic Zarko V.¹,Schreiber Stuart L.¹

Affiliation:

1. Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States

2. School of Chemistry, University of Bristol, Cantock’s Close, Bristol, BS8 1TS, United Kingdom

Funder

Howard Hughes Medical Institute

Engineering and Physical Sciences Research Council

National Institute of General Medical Sciences

Wenner-Gren Foundation

Eli Lilly and Company

Stiftelsen Bengt Lundqvists Minne

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

http://pubs.acs.org/doi/pdf/10.1021/jacs.6b04614

Reference37 articles.

1. Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

2. Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling

3. The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

4. When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis

5. Validating therapeutic targets through human genetics

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