Application of Phosphoramidate Pronucleotide Technology to Abacavir Leads to a Significant Enhancement of Antiviral Potency-Reference-Cited by-同舟云学术

Application of Phosphoramidate Pronucleotide Technology to Abacavir Leads to a Significant Enhancement of Antiviral Potency

Published:2005-04-16 Issue:10 Volume:48 Page:3504-3515
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

McGuigan Christopher¹,Harris Sarah A.¹,Daluge Susan M.¹,Gudmundsson Kristjan S.¹,McLean Ed W.¹,Burnette Thimysta C.¹,Marr Harry¹,Hazen Richard¹,Condreay Lynn D.¹,Johnson Lance¹,De Clercq Erik¹,Balzarini Jan¹

Affiliation:

1. Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, U.K., Medicinal Chemistry, Drug Metabolism and Pharmacokinetics, and Virology Departments, GlaxoSmithKline, Research Triangle Park, North Carolina, 27709, and Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0491400

Reference25 articles.

1. HIV-1 RNA, CD4 cell count and the risk of progression to AIDS and death during treatment with HIV-1 reverse transcriptase inhibitors

2. Abacavir-Lamivudine-Zidovudine vs Indinavir-Lamivudine-Zidovudine in Antiretroviral-Naive HIV-Infected AdultsA Randomized Equivalence Trial

Cited by 93 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Enhanced Remdesivir Analogues to Target SARS-CoV-2;Molecules;2023-03-13

2. Synthesis and Evaluation of Prodrugs of α-Carboxy Nucleoside Phosphonates;The Journal of Organic Chemistry;2022-10-25

3. Phosphorus through the looking glass;Science;2022-06-10

4. Developing Metal-Binding Isosteres of 8-Hydroxyquinoline as Metalloenzyme Inhibitor Scaffolds;Inorganic Chemistry;2022-05-04

5. Phosphoramidate Prodrugs Continue to Deliver, The Journey of Remdesivir (GS-5734) from RSV to SARS-CoV-2;ACS Medicinal Chemistry Letters;2022-02-21