Increasing Selectivity of CC Chemokine Receptor 8 Antagonists by Engineering Nondesolvation Related Interactions with the Intended and Off-Target Binding Sites-Reference-Cited by-同舟云学术

Increasing Selectivity of CC Chemokine Receptor 8 Antagonists by Engineering Nondesolvation Related Interactions with the Intended and Off-Target Binding Sites

Published:2009-07-17 Issue:23 Volume:52 Page:7706-7723
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shamovsky Igor¹,de Graaf Chris²,Alderin Lisa¹,Bengtsson Malena¹,Bladh Håkan¹,Börjesson Lena¹,Connolly Stephen³,Dyke Hazel J.⁴,van den Heuvel Marco⁴,Johansson Henrik¹,Josefsson Bo-Göran¹,Kristoffersson Anna¹,Linnanen Tero¹,Lisius Annea¹,Männikkö Roope⁵,Nordén Bo¹,Price Steve⁴,Ripa Lena¹,Rognan Didier²,Rosendahl Alexander⁶,Skrinjar Marco¹,Urbahns Klaus⁷

Affiliation:

1. Department of Medicinal Chemistry

2. Structural Chemogenomics Group, Laboratory of Therapeutic Innovation, UMR 7200 CNRS-UdS (Université de Strasbourg), 74 Route du Rhin, B.P. 24, F-67400 Illkirch, France

3. Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Loughborough, Leicestershire LE11 5RH, U.K.

4. Argenta Discovery Ltd, 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, U.K.

5. Department of Safety Pharmacology, Safety Assessment U.K., AstraZeneca R&D Alderley Park, Macclesfield SK10 4TG, U.K.

6. Department of Biological Sciences

7. Global Respiratory and Inflammation Research, AstraZeneca R&D Charnwood, Loughborough, Leicestershire LE11 5RH, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900713y

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5. The 2.6 Angstrom Crystal Structure of a Human A 2A Adenosine Receptor Bound to an Antagonist

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