Increasing Selectivity of CC Chemokine Receptor 8 Antagonists by Engineering Nondesolvation Related Interactions with the Intended and Off-Target Binding Sites

Author:

Shamovsky Igor1,de Graaf Chris2,Alderin Lisa1,Bengtsson Malena1,Bladh Håkan1,Börjesson Lena1,Connolly Stephen3,Dyke Hazel J.4,van den Heuvel Marco4,Johansson Henrik1,Josefsson Bo-Göran1,Kristoffersson Anna1,Linnanen Tero1,Lisius Annea1,Männikkö Roope5,Nordén Bo1,Price Steve4,Ripa Lena1,Rognan Didier2,Rosendahl Alexander6,Skrinjar Marco1,Urbahns Klaus7

Affiliation:

1. Department of Medicinal Chemistry

2. Structural Chemogenomics Group, Laboratory of Therapeutic Innovation, UMR 7200 CNRS-UdS (Université de Strasbourg), 74 Route du Rhin, B.P. 24, F-67400 Illkirch, France

3. Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Loughborough, Leicestershire LE11 5RH, U.K.

4. Argenta Discovery Ltd, 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, U.K.

5. Department of Safety Pharmacology, Safety Assessment U.K., AstraZeneca R&D Alderley Park, Macclesfield SK10 4TG, U.K.

6. Department of Biological Sciences

7. Global Respiratory and Inflammation Research, AstraZeneca R&D Charnwood, Loughborough, Leicestershire LE11 5RH, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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