Identification and Optimization of Pyrrolidine Derivatives as Highly Potent Ghrelin Receptor Full Agonists-Reference-Cited by-同舟云学术

Identification and Optimization of Pyrrolidine Derivatives as Highly Potent Ghrelin Receptor Full Agonists

Published:2020-08-12 Issue:17 Volume:63 Page:9705-9730
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cooper Martin,Llinas Antonio^ORCID,Hansen Peter,Caffrey Moya,Ray Asim,Sjödin Stina¹,Shamovsky Igor^ORCID,Wada Hiroki,Jellesmark Jensen Tina²,Sivars Ulf,Hultin Leif³,Andersson Ulf⁴,Lundqvist Sara⁵,Gedda Karin⁶,Jinton Lisa,Krutrök Nina,Lewis Richard^ORCID,Jansson Paul,Gardelli Cristina^ORCID

Affiliation:

1. Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Mölndal SE-43183, Sweden

2. Early Clinical Development, Research and Early Development, Respiratory, Inflammation and Autoimmune (RIA), BioPharmaceuticals R&D, AstraZeneca, Mölndal SE-43183, Sweden

3. In Vivo Imaging Sciences, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Mölndal SE-43183, Sweden

4. Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Mölndal SE-43183, Sweden

5. Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Mölndal SE-43183, Sweden

6. Precision Medicine, Oncology R&D, AstraZeneca, Mölndal SE-43183, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00828

Reference41 articles.

1. Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract

2. The Homeostatic Force of Ghrelin

3. Ghrelin

4. Ghrelin receptor inverse agonists as a novel therapeutic approach against obesity‐related metabolic disease

5. Rational Design, Synthesis, and Pharmacological Characterization of Novel Ghrelin Receptor Inverse Agonists as Potential Treatment against Obesity-Related Metabolic Diseases

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