Discovery of 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, Selective, and Orally Active 5-HT1A/B/D Receptor Antagonist-Reference-Cited by-同舟云学术

Discovery of 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, Selective, and Orally Active 5-HT1A/B/D Receptor Antagonist

Published:2010-11-05 Issue:23 Volume:53 Page:8228-8240
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Leslie Colin P.¹,Biagetti Matteo¹,Bison Silvia¹,Bromidge Steven M.²,Di Fabio Romano¹,Donati Daniele¹,Falchi Alessandro¹,Garnier Martine J.¹,Jaxa-Chamiec Albert¹,Manchee Gary¹,Merlo Giancarlo¹,Pizzi Domenica A.¹,Stasi Luigi P.¹,Tibasco Jessica¹,Vong Antonio²,Ward Simon E.²,Zonzini Laura¹

Affiliation:

1. Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline SpA, Medicines Research Centre, Via A. Fleming 4, 37135 Verona, Italy

2. Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100714c

Reference43 articles.

1. The spectrum of behaviors influenced by serotonin

2. A review of the role of serotonin receptors in psychiatric disorders

3. Therapeutic potential of serotonin antagonists in depressive disorders

4. Serotonin and Drug-Induced Therapeutic Responses in Major Depression, Obsessive–Compulsive and Panic Disorders

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Combining AI and traditional screening for discovery of a potent ROCK2 inhibitor against lymphoma;Journal of Molecular Structure;2024-05

2. Surprising lipophilicity observations identify unexpected conformational effects;Bioorganic & Medicinal Chemistry Letters;2022-08

3. Surprising Lipophilicity Observations Identify Unexpected Conformational Effects;SSRN Electronic Journal;2022

4. Controlling the selectivity of aminergic GPCR ligands from the extracellular vestibule;Bioorganic Chemistry;2021-06

5. Vinylogous Aza‐Michael Addition of Urea Derivatives with p ‐Quinone Methides Followed by Oxidative Dearomative Cyclization: Approach to Spiroimidazolidinone Derivatives;Advanced Synthesis & Catalysis;2021-04-12