The Role of Amino Acid Sequence in the Self-Association of Therapeutic Monoclonal Antibodies: Insights from Coarse-Grained Modeling-Reference-Cited by-同舟云学术

The Role of Amino Acid Sequence in the Self-Association of Therapeutic Monoclonal Antibodies: Insights from Coarse-Grained Modeling

Published:2013-01-25 Issue:5 Volume:117 Page:1269-1279
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Chaudhri Anuj¹,Zarraga Isidro E.²,Yadav Sandeep²,Patapoff Thomas W.³,Shire Steven J.²,Voth Gregory A.¹

Affiliation:

1. Department of Chemistry, James Franck Institute, Institute for Biophysical Dynamics and Computation Institute, University of Chicago, Chicago Illinois 60637, United States

2. Late Stage Pharmaceutical Development, Genentech Inc., 1 DNA Way, S. San Francisco, California 94080, United States

3. Early Stage Pharmaceutical Development, Genentech Inc., 1 DNA Way, S. San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jp3108396

Reference47 articles.

1. Immunotherapy: past, present and future

2. What's fueling the biotech engine—2008

3. Therapeutic antibodies for autoimmunity and inflammation

4. Challenges in the development of high protein concentration formulations

5. Formulation and manufacturability of biologics

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