Abstract
The multiplication of bacteria in the largely undefined and changing environment of host tissues is an essential feature of any infection. Bacterial behaviour is determined both by genetic structures and also by the environment. Little is known about the effect that host factors may have on invading bacteria nor about the way in which alterations in bacterial properties aid proliferationin vivo. Recently our understanding of one feature of this environm ent and of the way in which pathogenic bacteria adapt to it has increased considerably. We now know that the amount of iron that might be readily available to bacteria in body fluids is extremely small. This iron-restricted environment induces phenotypic changes both in the metabolism and in the composition of the outer membrane of bacteria growingin vivo. These and other host-induced changes are now providing a fresh insight into the capability of bacteria to multiplyin vivoduring infection.
Subject
Industrial and Manufacturing Engineering,General Agricultural and Biological Sciences,General Business, Management and Accounting,Materials Science (miscellaneous),Business and International Management
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