Abstract
Primary afferent C fibres can be subdivided into a number of subgroups on the basis of cytochemistry or receptor binding characteristics. Numerous peptides have been localized to dorsal root ganglia, yet these appear to be only found in approximately 50 % of small perikarya. A large proportion of the remaining small cells do not contain peptides but are identifiable in rodents by their content of a fluoride resistant acid phosphatase. Attempts have been made to correlate particular biochemical types with particular receptive field profiles, with rather modest success. As an alternative we suggest, principally from an analysis of skin afferents, that peptide- and nonpeptide-containing afferents are two distinct C fibre pathways innervating similar peripheral structures and conveying similar information, but to different areas within the dorsal horn. Morphological evidence also suggests that these two subsystems form either glomerular or simple synaptic arrangements in the dorsal horn. The significance of parallel pathways for the processing of nociceptive information is briefly discussed.
Subject
Industrial and Manufacturing Engineering,General Agricultural and Biological Sciences,General Business, Management and Accounting,Materials Science (miscellaneous),Business and International Management
Reference35 articles.
1. The origin, distribution and synaptic relationships of substance P axons in rat spinal cord. comp. Neurol. J. comp;Barber R. P.;Neurol.,1979
2. Substance pin spinal cord dorsal horn decreases following peripheral nerve injury
3. Physiology and morphology of substantia gelatinosa neurons intracellularly stained with horseradish peroxidase. J. comp;Bennett G. J.;Neurol.,1980
4. Enkephalin immunoreactive stalked cells and lamina IIb islet cells in cat substantia gelatinosa
5. THE SUBSTANTIA GELATINOSA OF THE SPINAL CORD
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