Affiliation:
1. Instituto de Medicina Molecular—João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
Abstract
Parasitic diseases, such as sleeping sickness, Chagas disease and malaria, remain a major cause of morbidity and mortality worldwide, but particularly in tropical, developing countries. Controlling these diseases requires a better understanding of host–parasite interactions, including a deep appreciation of parasite distribution in the host. The preferred accumulation of parasites in some tissues of the host has been known for many years, but recent technical advances have allowed a more systematic analysis and quantifications of such tissue tropisms. The functional consequences of tissue tropism remain poorly studied, although it has been associated with important aspects of disease, including transmission enhancement, treatment failure, relapse and clinical outcome. Here, we discuss current knowledge of tissue tropism in
Trypanosoma
infections in mammals, describe potential mechanisms of tissue entry, comparatively discuss relevant findings from other parasitology fields where tissue tropism has been extensively investigated, and reflect on new questions raised by recent discoveries and their potential impact on clinical treatment and disease control strategies.
Funder
European Molecular Biology Organization
Fundação para a Ciência e a Tecnologia
H2020 European Research Council
Subject
General Biochemistry, Genetics and Molecular Biology,Immunology,General Neuroscience
Reference188 articles.
1. Phototropism: Growing towards an Understanding of Plant Movement
2. The silent path to thousands of merozoites: the Plasmodium liver stage
3. Trypanosomatids: Odd Organisms, Devastating Diseases
4. The Burden of Chagas Disease: Estimates and Challenges
5. World Health Organization. 2018 Trypanosomiasis human African (sleeping sickness) . Fact Sheet. See https://www.who.int/news-room/fact-sheets/detail/trypanosomiasis-human-african-(sleeping-sickness) (accessed on 19 March 2019).
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