Recent advancements in cloning by somatic cell nuclear transfer

Author:

Ogura Atsuo12,Inoue Kimiko12,Wakayama Teruhiko34

Affiliation:

1. RIKEN BioResource Center, Tsukuba, Ibaraki, Japan

2. Graduate School of Life and Environmental Science, University of Tsukuba, Ibaraki, Japan

3. Laboratory for Genomic Reprogramming, RIKEN Center for Developmental Biology, Kobe, Japan

4. Faculty of Life and Environmental Sciences, Yamanashi University, Yamanashi, Japan

Abstract

Somatic cell nuclear transfer (SCNT) cloning is the sole reproductive engineering technology that endows the somatic cell genome with totipotency. Since the first report on the birth of a cloned sheep from adult somatic cells in 1997, many technical improvements in SCNT have been made by using different epigenetic approaches, including enhancement of the levels of histone acetylation in the chromatin of the reconstructed embryos. Although it will take a considerable time before we fully understand the nature of genomic programming and totipotency, we may expect that somatic cell cloning technology will soon become broadly applicable to practical purposes, including medicine, pharmaceutical manufacturing and agriculture. Here we review recent progress in somatic cell cloning, with a special emphasis on epigenetic studies using the laboratory mouse as a model.

Publisher

The Royal Society

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

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