Affiliation:
1. University of California, San Francisco, CA 94158, USA
Abstract
Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in species throughout the animal kingdom. This life-extension pathway, the first to be defined, was discovered through genetic studies in the small roundwormCaenorhabditis elegans. This discovery is described here.
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology
Cited by
272 articles.
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