Pluripotency and nuclear reprogramming-Reference-Cited by-同舟云学术

Pluripotency and nuclear reprogramming

Published:2008-03-28 Issue:1500 Volume:363 Page:2079-2087
ISSN:0962-8436
Container-title:Philosophical Transactions of the Royal Society B: Biological Sciences
language:en
Short-container-title:Phil. Trans. R. Soc. B

Author:

Yamanaka Shinya¹²

Affiliation:

1. Center for iPS Cell Research & Application, Kyoto University, 53 Kawahara-machi, ShogoinSakyo-ku, Kyoto 606-8507, Japan

2. CREST, JSTKawaguchi 332-0012, Japan

Abstract

Embryonic stem cells are promising donor cell sources for cell transplantation therapy, which may in the future be used to treat various diseases and injuries. However, as is the case for organ transplantation, immune rejection after transplantation is a potential problem with this type of therapy. Moreover, the use of human embryos presents serious ethical difficulties. These issues may be overcome if pluripotent stem cells are generated from patients' somatic cells. Here, we review the molecular mechanisms underlying pluripotency and the currently known methods of inducing pluripotency in somatic cells.

Publisher

The Royal Society

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

Link

https://royalsocietypublishing.org/doi/pdf/10.1098/rstb.2008.2261

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