The Role of SOX 2 Gene in Cervical Cancer: Focus on Iron Death and Construct a Predictive Model

Abstract

Abstract Background The intricate interplay between stemness markers and cell death pathways significantly influences the pathophysiology of cervical cancer. SOX2, a pivotal regulator of stem cell pluripotency, has recently been implicated in the modulation of ferroptosis, a specialized form of iron-dependent cell death, in cancer dynamics. This study delineates the role of SOX2 in the ferroptotic landscape of cervical carcinoma. Objective To delineate the association between SOX2 expression and ferroptosis in cervical cancer and develop a robust, SOX2-centric predictive model for patient prognosis, enhancing personalized therapeutic approaches. Methods A multi-dimensional approach integrating advanced bioinformatics, comprehensive molecular profiling, and state-of-the-art machine learning algorithms was employed to assess SOX2 expression patterns and their correlation with ferroptotic markers in cervical cancer tissues. The prognostic model was meticulously crafted, incorporating SOX2 expression levels and ferroptosis indicators. Results The investigation unveiled a profound and intricate correlation between SOX2 expression and ferroptotic processes in cervical cancer, substantiated by robust molecular evidence. The developed predictive model, underpinned by SOX2 expression, exhibited superior predictive accuracy for patient prognosis, potentially guiding therapeutic decision-making. Conclusion This study underscores the critical role of SOX2 in orchestrating the ferroptotic pathway in cervical cancer, presenting a novel prognostic framework. The SOX2-centric predictive model emerges as a significant advancement in prognostic evaluation, offering a gateway to precision oncology in the realm of gynecologic oncology.