1. Department of Mathematics, University of Michigan, 530 Church Street, Ann Arbor, MI 48109-1043, USA
2. Department of Anesthesiology, University of Michigan, 530 Church Street, Ann Arbor, MI 48109-1043, USA
3. Computational Medicine and Bioinformatics, University of Michigan, 530 Church Street, Ann Arbor, MI 48109-1043, USA