Cortical nitric oxide required for presynaptic long-term potentiation in the insular cortex-Reference-Cited by-同舟云学术

Cortical nitric oxide required for presynaptic long-term potentiation in the insular cortex

Published:2024-06-10 Issue:1906 Volume:379 Page:
ISSN:0962-8436
Container-title:Philosophical Transactions of the Royal Society B: Biological Sciences
language:en
Short-container-title:Phil. Trans. R. Soc. B

Author:

Yamamoto Kiyofumi¹²^ORCID,Chen Qi-Yu²³⁴^ORCID,Zhou Zhaoxiang²⁵^ORCID,Kobayashi Masayuki¹^ORCID,Zhuo Min²³⁵^ORCID

Affiliation:

1. Department of Pharmacology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai , Chiyoda-ku, Tokyo 101-8310, Japan

2. Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King's College Circle , Toronto, Ontario M5S 1A8, Canada

3. Zhuomin Institute for Brain Research , Qingdao 266000, People's Republic of China

4. CAS Key Laboratory of Brain Connectome and Manipulation, Interdisciplinary Center for Brain Information, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences Shenzhen Institute of Advanced Technology , Shenzhen 518055, People's Republic of China

5. Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University , Guangzhou 510130, People's Republic of China

Abstract

Nitric oxide (NO) is a key diffusible messenger in the mammalian brain. It has been proposed that NO may diffuse retrogradely into presynaptic terminals, contributing to the induction of hippocampal long-term potentiation (LTP). Here, we present novel evidence that NO is required for kainate receptor (KAR)-dependent presynaptic form of LTP (pre-LTP) in the adult insular cortex (IC). In the IC, we found that inhibition of NO synthase erased the maintenance of pre-LTP, while the induction of pre-LTP required the activation of KAR. Furthermore, NO is essential for pre-LTP induced between two pyramidal cells in the IC using the double patch-clamp recording. These results suggest that NO is required for homosynaptic pre-LTP in the IC. Our results present strong evidence for the critical roles of NO in pre-LTP in the IC. This article is part of a discussion meeting issue ‘Long-term potentiation: 50 years on’.

Funder

Canadian Institute for Health Research operating Grants

MEXT KAKENHI Grant

Publisher

The Royal Society

Link

https://royalsocietypublishing.org/doi/pdf/10.1098/rstb.2023.0475

Reference43 articles.

1. A synaptic model of memory: long-term potentiation in the hippocampus

2. Cortical excitation and chronic pain

3. Synaptic Mechanisms of Associative Memory in the Amygdala

4. Synaptic signalling in cerebellar plasticity

5. Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Long-term potentiation: 50 years on: past, present and future;Philosophical Transactions of the Royal Society B: Biological Sciences;2024-06-10

2. Cortical nitric oxide required for presynaptic long-term potentiation in the insular cortex;Philosophical Transactions of the Royal Society B: Biological Sciences;2024-06-10