Affiliation:
1. Department of Occupational Disease, Yantaishan Hospital (Yantai Occupational Disease Hospital), Yantai 264025, Shandong, PR China
Abstract
Nanometer silica dioxide (nano-SiO2) is a widely utilized material in everyday applications; however, it exhibits toxic side effects on the human body. This study aims to provide reliable research basis for theoretical guidance in mitigating the toxic effects of nano-SiO2
in future applications by analyzing the mechanism of its effect on bronchial epithelial cells. In this experiment, under nano-SiO2 intervention, the proliferation and migration capacities of bronchial epithelial cells decreased (P < 0.05); apoptosis capacity increased
(P < 0.05); the P13K/AKT/mTOR signaling pathway was inhibited (P < 0.05), and the oxidative stress reaction and inflammatory response was intensified (P < 0.05). Thus, we can tentatively infer that nano-SiO2 causes apoptosis of the bronchial epithelial
cells by inhibiting the P13K/AKT/mTOR signaling pathway and accelerates the activation of oxidative stress, thus leading to toxic effects on bronchial epithelial cells.
Publisher
American Scientific Publishers
Subject
General Materials Science
Cited by
2 articles.
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