Affiliation:
1. College of Anesthesiology, Guizhou Medical University, Guiyang, 550004, Guizhou, China
2. Department of Pain, Guizhou Orthopaedic Hospital, Guiyang, 550004, Guizhou, China
Abstract
This study aimed to investigate the effect and mechanism of triamcinolone acetonide on nerve root inflammation and epidural adhesion in rabbits. The experiment involved 30 male New Zealand white rabbits, which were divided into three groups: Model, Dexamethasone, and Triamcinolone.
After establishing the rabbit model of nerve root inflammation and epidural adhesion, dexamethasone and triamcinolone acetonide were injected through the epidural catheter. The results showed that triamcinolone acetonide significantly reduced nerve root inflammation, epidural adhesion, and
nerve root pain. It also decreased the mRNA expression levels of NF-KB, TLR9, IL-6, and TNF-α in spinal cord tissue and spinal nerve roots. Compared with the dexamethasone group, the triamcinolone group had a lower Rydell-Balaz score, indicating less epidural adhesion. The Paw
Withdraw Threshold and Paw Withdraw Latency decreased significantly in the triamcinolone group compared to the model group, and there was no obvious nerve root inflammatory reaction in the triamcinolone group. Therefore, epidural triamcinolone acetonide injection may be an effective treatment
to reduce nerve root inflammation, epidural adhesion, and nerve root pain by inhibiting the NF-KB/TLR9-mediated inflammatory response.
Publisher
American Scientific Publishers
Subject
Pharmaceutical Science,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering
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