Optimized Green Synthesis and Anticancer Potential of Silver Nanoparticles Using Juniperus procera Extract Against Lung Cancer Cells

Abstract

Silver nanoparticles (AgNPs) have been considered promising candidates for medical practices in various fields. This study proposed an efficient, economical, uncomplicated, and reliable method to synthesize AgNPs utilizing leaf and fruit extracts of Juniperus procera (J. procera) as capping, reducing, and stabilizing agents. The study includes optimizing the green synthesis conditions to produce stable AgNPs with high yields, acceptable particle size, and shape, hence, AgNPs may be used for different medical purposes through the improvement of their properties. Several spectroscopic and other analyses performed characterization of the fabricated AgNPs, and the results show stable and spherical AgNPs between 14 and 18 nm in size. The study also evaluated the anticancer activities of the biosynthesized AgNPs using J. procera fruit and leaf extracts against in vitro lung cancer A549 and H1975 cells. The results demonstrate the high toxicity of the biosynthesized AgNPs against in vitro lung cancer cells, supporting therapeutic and biomedical applications of AgNPs.