Oxaliplatin (OXA)-Loaded Nanoparticles Inhibit the Proliferation and Migration of Hepatocellular Carcinoma Cells

Abstract

Our study proposed to explore the impact of OXA-loaded nanoparticles on hepatocellular carcinoma (HCC) cell proliferation and migration. The nanoparticles (OXA@ cRGD-TAT-PLGA) were successfully established after optimizing the preparation method. The nanoparticle size was approximately 500 nm under the scanning electron microscope. The nanoparticles were stable with regular spheres. The loading content (LC) of OXA-loaded PLGA nanoparticles was 3.5%. The encapsulation efficiency (EE) was 61.5% with stable release processing. This was an ideal sustained-release material. The average particle size of four nanoparticles was approximately 200–300 nm with negative charges. The proliferation of HCC cells treated with blank nanoparticles was not significantly affected, indicating that blank nanoparticles showed no cytotoxicity, whereas OXA@PLGA-TAT-cRGD significantly promoted apoptosis and inhibited the migration and proliferation of HepG2 cells. The drug delivery vector modified with cRGD peptide constructs effectively delivered drugs into HCC cells. OXA@PLGA-TAT-cRGD showed promising effects on the promotion of apoptosis and inhibition of migration in HCC cells, thereby making it an ideal drug delivery material.