Synthesised silver nanoparticles mediate interdigitated nanobiosensing for sensitive Pneumonia identification

Author:

Su Lili1,Ren Zhenqing2,Chen Xia3,Feng Guoqin2,Zhou Lijuan2

Affiliation:

1. Department of Nursing, Taizhou Municipal Fifth People’s Hospital, Taizhou, 225300, Jiangsu Province, China

2. Department of Nursing, Taizhou Municipal People’s Hospital, Taizhou, 225300, Jiangsu Province, China

3. Department of Cardiothoracic Surgery, Taizhou Municipal People’s Hospital, Taizhou, 225300, Jiangsu Province, China

Abstract

Pneumonia is a life-threatening disease and at present, a large population of humans is affected by pneumonia worldwide. It is a serious issue causing complications of acquired immune deficiency syndrome infection. Most people are affected in low-and middle-income countries. Until now pneumonia is mainly diagnosed by smear microscopy and is not easily available in the area of low-income settings. This research was conducted with a sensing strategy on interdigitated microelectrode (IDME) to identify the lower level of the target, ‘procalcitonin’. In addition, procalcitonin can distinguish the community-acquired viral pathogens, which helps to provide a suitable treatment. IDME was physically modified by a silver nanoparticle, and an anti-procalcitonin antibody was attached to a silver nanoparticle with amine and aldehyde linkers. On this IDME, procalcitonin was quantified in a dose-dependent manner (10–320 ng/mL) and calculated the detection limit to 10 ng/mL on a linear coefficient regression analysis [y = 2.2821×−2.6871; R2 = 0.9904]. Specific performances with control proteins that did not increase the current were revealed the specific identification of procalcitonin. This experiment created a sensing strategy to identify procalcitonin as a suitable biomarker.

Publisher

American Scientific Publishers

Subject

General Materials Science

Reference38 articles.

1. Pneumonia

2. Pneumonia detection from chest X-ray images based on convolutional neural network;Zhang;Electronics (Switzerland), Electonic,2021

3. Diagnostic yield of a direct quantitative smear of lower respiratory tract secretions in patients with suspected pneumonia compared to a semi-quantitative culture;Shokouhi;Tanaffos,2017

4. Electronic nose prediction of a clinical pneumonia score: Biosensors and microbes;Hanson;Anesthesiology,2005

5. Establishment and application of a multiple cross displacement amplification coupled with nanoparticle-based lateral flow biosensor assay for detection of mycoplasma pneumoniae;Wang;Frontiers in Cellular and Infection Microbiology,2019

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3