Sequential Injection Amperometric Determination of Glucose in Saliva Using a Screen-Printed Electrode Modified with a Gold–Cobalt Binary System

Abstract

The catalytic activity of particles of gold, cobalt, and a gold–cobalt binary system electrodeposited on the surface of planar carbon electrodes was found in the oxidation of glucose in a neutral medium. The amperometric response of a screen-printed electrode modified with a gold–cobalt binary system was used as an analytical signal in the determination of glucose in a sequential injection system. The linear logarithmic dependence of current on the glucose concentration was observed in the range from 5 × 10–8 to 5 × 10–2 M. The use of a screen-printed electrode modified with a gold–cobalt binary system as an amperometric detector in a sequential injection system makes it possible to selectively determine glucose in saliva in the concentration range used for medical diagnosis.