Copper-containing nanosystems based on macromolecular hydrophilic stabilizers

Abstract

An original method for the synthesis of copper-containing nanosystems for biomedical applications using hydrazine hydrate as a reducing agent, intermediate stage of formation of complex ion [Cu(NH3)4]2+, which allows to obtain Cu0 nanoparticles without impurities of oxides has been developed. As a macromolecular hydrophilic stabilizer copolymer of 2-deoxy‑2-methacrylamido-D‑glucose with 2-dimethylaminoethylmethaacrylate or bovine serum albumin were used. It has been shown that such stabilization allows to achieve almost unimodal distribution of copper nanoparticles in aqueous solutions due to their rather good shielding by macromolecules.