Relationship between serum bilirubin levels and presence of fragmented QRS in patients with acute coronary syndrome

Abstract

Aim: To assess the relationship between serum bilirubin levels and fragmented QRS (fQRS), and their association with adverse events in patients with acute coronary syndrome. Methods: This study included a total of 736 patients. Laboratory results such as bilirubin levels, renal and liver function tests were obtained from the first available blood sample. Results: Left ventricular ejection fraction, end-diastolic diameter and total bilirubin level were significantly lower in fQRS (+) group than in the control group (45.0 [40.0–55.0] vs 50.0 [45.0–60.0]%; p < 0.001; 4.7 [4.6–5.1] vs 4.7 [4.5–4.9] cm; p < 0.001; 0.66 [0.49–5.1] vs 0.72 [0.53–0.97] md/dl; p = 0.017); respectively. Occurrence of adverse events was significantly higher in fQRS (+) group (32.5 vs 20.5 %; p = 0.013) during mean 1-year follow-up period. Conclusion: Total bilirubin level is an independent predictor of fQRS formation, which is associated with the presence of adverse events in patients with acute coronary syndrome.