Association between congenital heart disease and NKX2.5 gene polymorphisms: systematic review and meta-analysis-Reference-Cited by-同舟云学术

Association between congenital heart disease and NKX2.5 gene polymorphisms: systematic review and meta-analysis

Published:2020-12 Issue:18 Volume:14 Page:1747-1757
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

González-Castro Thelma B¹^ORCID,Tovilla-Zárate Carlos A²^ORCID,López-Narvaez María L³^ORCID,Juárez-Rojop Isela E⁴^ORCID,Calderón-Colmenero Juan⁵^ORCID,Sandoval Juan P⁶^ORCID,García-Montes José A⁶,Blachman-Braun Ruben⁷^ORCID,Castillo-Avila Rosa G⁴⁸^ORCID,García-Flores Esbeidy⁸^ORCID,Cazarín-Santos Benny G⁸^ORCID,Borgonio-Cuadra Verónica M⁹^ORCID,Posadas-Sánchez Rosalinda¹⁰^ORCID,Vargas-Alarcón Gilberto⁸^ORCID,Rodríguez-Pérez José M⁸^ORCID,Pérez-Hernández Nonanzit⁸^ORCID

Affiliation:

1. Multidisciplinary Academic Division of Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tabasco, Mexico

2. Multidisciplinary Academic Division of Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco, Mexico

3. General Hospital of Yajalón Manuel Velasco Siles, Secretaría de Salud, Yajalón, Chiapas, Mexico

4. Academic Division of Health Sciences, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, Mexico

5. Department of Pediatric Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico

6. Laboratory of Hemodynamics & Intervention in Congenital Heart Disease, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico

7. Department of Urology, University of Miller School of Medicine, Miami, FL 33136, USA

8. Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico

9. Department of Genetics, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, Mexico

10. Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico

Abstract

Aim: To analyze the association of NKX2.5 gene with congenital heart disease (CHD), and to determine if the variants rs703752, rs3729753 and rs2277923 increase the risk for developing CHD. Materials & methods: PubMed, EBSCO and Web of Science databases were screened to identify eligible studies. Through a comprehensive meta-analysis software, the association between NKX2.5 gene variants and susceptibility of CHD was calculated by pooled odd ratio (ORs) and 95% CI. Results: We observed that the allelic model of rs703752 and rs2277923 increased the risk in the overall population: OR = 1.24; 95% CI: 1.00–1.55; Z p-value = 0.049; OR = 1.18; 95% CI: 0.01–1.37; Z p-value = 0.036; respectively. Conclusion: Our results suggested that the rs703752 and rs2277923 polymorphisms of the NKX2.5 gene are associated with CHD.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2020-0190

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