Therapeutic targeting of gastrointestinal cancer stem cells-Reference-Cited by-同舟云学术

Therapeutic targeting of gastrointestinal cancer stem cells

Published:2019-04 Issue:4 Volume:14 Page:331-343
ISSN:1746-0751
Container-title:Regenerative Medicine
language:en
Short-container-title:Regenerative Medicine

Author:

Stem Jonathan¹,Flickinger John C²,Merlino Dante²,Caparosa Ellen M¹²,Snook Adam E²,Waldman Scott A²

Affiliation:

1. Departments of Surgery, Sidney, 1020 Locust St, JAH368, Philadelphia, PA 19107, USA

2. Pharmacology & Experimental Therapeutics, Sidney, 1020 Locust St, JAH368, Philadelphia, PA 19107, USA

Abstract

Gastrointestinal cancers remain a tremendous burden on society. Despite advances in therapy options, including chemotherapy and radiation, cancer mortality from recurrences and metastases occur frequently. Cancer stem cells (CSCs) drive disease recurrence and metastasis, as these cells are uniquely equipped to self-renew and evade therapy. Therefore, cancer eradication requires treatment strategies that target CSCs in addition to differentiated cancer cells. This review highlights current literature on therapies targeting CSCs in gastrointestinal cancer.

Publisher

Future Medicine Ltd

Subject

Embryology,Biomedical Engineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/rme-2018-0146

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