Serum-based protein profiles of Alzheimer's disease and mild cognitive impairment in elderly Hispanics-Reference-Cited by-同舟云学术

Serum-based protein profiles of Alzheimer's disease and mild cognitive impairment in elderly Hispanics

Published:2016-06 Issue:3 Volume:6 Page:203-213
ISSN:1758-2024
Container-title:Neurodegenerative Disease Management
language:en
Short-container-title:Neurodegenerative Disease Management

Author:

Villarreal Alcibiades E¹²,O'Bryant Sid E³,Edwards Melissa⁴,Grajales Shantal¹,Britton Gabrielle B¹,

Affiliation:

1. Centro de Neurociencias y Unidad de Investigación Clínica, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad del Saber 219, Clayton, Apartado Postal 0843-01103, República de Panamá

2. Department of Biotechnology, Acharya Nagarjuna University, Guntur, India

3. Institute for Healthy Aging, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA

4. Department of Psychology, University of North Texas, 1155 Union Circle, Denton, TX 76203, USA

Abstract

Aim: To describe the biomarker profiles in elderly Panamanians diagnosed with Alzheimer's disease (AD), mild cognitive impairment (MCI) or no impairment using serum-based biomarkers. Methods: Twenty-four proteins were analyzed using an electrochemiluminescence-based multiplex biomarker assay platform. A biomarker profile was generated using random forest analyses. Results: Two proteins differed among groups: IL-18 and T-lymphocyte-secreted protein I-309. The AD profile was highly accurate and independent of age, gender, education and Apolipoprotein E ε4 status. AD and MCI profiles had substantial overlap among the top markers, suggesting common functions in AD and MCI but differences in their relative importance. Conclusion: Our results underscore the potential influence of genetic and environmental differences within Hispanic populations on the proteomic profile of AD.

Publisher

Future Medicine Ltd

Subject

Clinical Neurology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nmt-2015-0009

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