No association between markers of systemic inflammation and endothelial dysfunction with Alzheimer’s disease progression: a longitudinal study
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Published:2024-07-31
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ISSN:2509-2723
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Container-title:GeroScience
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language:en
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Short-container-title:GeroScience
Author:
van Setten Arne, Uleman Jeroen F.ORCID, Melis René J. F., Lawlor Brian, Riksen Niels P., Claassen Jurgen A. H. R., de Heus Rianne A. A., Segurado Ricardo, Kennelly Sean, Rikkert Marcel G. M. Olde, Howard Robert, Pasquier Florence, Börjesson-Hanson Anne, Tsolaki Magda, Lucca Ugo, Molloy D. William, Coen Robert, Riepe Matthias W., Kálmán János, Kenny Rose Anne, Cregg Fiona, O’Dwyer Sarah, Walsh Cathal, Adams Jessica, Banzi Rita, Breuilh Laetitia, Daly Leslie, Hendrix Suzanne, Aisen Paul, Gaynor Siobhan, Sheikhi Ali, Taekema Diana G., Verhey Frans R., Nemni Raffaello, Nobili Flavio, Franceschi Massimo, Frisoni Giovanni, Zanetti Orazio, Konsta Anastasia, Anastasios Orologas, Nenopoulou Styliani, Tsolaki-Tagaraki Fani, Pakaski Magdolna, Dereeper Olivier, de la Sayette Vincent, Sénéchal Olivier, Lavenu Isabelle, Devendeville Agnès, Calais Gauthier, Crawford Fiona, Mullan Michael, Berglund Maria A., Claassen Jurgen A., de Heus Rianne A., de Jong Daan L. K., Godefroy Olivier, Hutchinson Siobhan, Ioannou Aikaterini, Jonsson Michael, Kent Annette, Kern Jürgen, Nemtsas Petros, Panidou Minoa-Kalliopi, Abdullah Laila, Paris Daniel, Santoso Angelina M., van Spijker Gerrita J., Spiliotou Martha, Thomoglou Georgia, Wallin Anders,
Abstract
Abstract
Introduction
Systemic inflammation and endothelial dysfunction are potentially modifiable factors implicated in Alzheimer’s disease (AD), which offer potential therapeutic targets to slow disease progression.
Methods
We investigated the relationship between baseline circulating levels of inflammatory (TNF-α, IL-1ß) and endothelial cell markers (VCAM-1, ICAM-1, E-selectin) and 18-month cognitive decline (ADAS-cog12) in 266 mild-to-moderate AD patients from the NILVAD study. We employed individual growth models to examine associations, potential mediation, and interaction effects while adjusting for confounders.
Results
The average increase in ADAS-cog12 scores over all patients was 8.1 points in 18 months. No significant association was found between the markers and the rate of cognitive decline. Mediation analysis revealed no mediating role for endothelial cell markers, and interaction effects were not observed.
Discussion
Our results do not support the role of systemic inflammation or endothelial dysfunction in progression in persons with AD.
Funder
Seventh Framework Programme Alzheimer's Drug Discovery Foundation ZonMw Copenhagen University
Publisher
Springer Science and Business Media LLC
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