Biomarker use is associated with reduced clinical trial failure risk in metastatic melanoma

Author:

Rubinger Daniel A1,Hollmann Sarah S1,Serdetchnaia Viktoria1,Ernst D Scott2,Parker Jayson L1

Affiliation:

1. Biology Department, University of Toronto Mississauga, William Davis Building, Room 2071, Mississauga, ON, L5L 1C6, Canada

2. Division of Medical Oncology, London Regional Cancer Program, 790 Commissioners Road East, London, ON, N6A 4L6, Canada

Abstract

Given the high morbidity and mortality associated with metastatic melanoma, considerable attention has been paid to identifying potential therapies. Until recently, few therapies have been specifically approved for treating metastatic melanoma. In an attempt to increase clinical trial successes, many therapies are implementing biomarkers for patient stratification. This strategy narrows down the population in an effort to identify appropriate subpopulations that have increased efficacy or fewer safety concerns. However, the addition of a biomarker constitutes an additional risk to clinical development and may therefore increase the overall clinical trial risk. Here, we examine the clinical trial success rate for therapies targeting metastatic melanoma. In addition, we identify the impact that biomarkers have had on the clinical development of this disease.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

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