Prognostic values of Ki-67 in neoadjuvant setting for breast cancer: a systematic review and meta-analysis-Reference-Cited by-同舟云学术

Prognostic values of Ki-67 in neoadjuvant setting for breast cancer: a systematic review and meta-analysis

Published:2017-05 Issue:11 Volume:13 Page:1021-1034
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Li Lun¹,Han Dongdong²,Wang Xiaowei³,Wang Quan⁴,Tian Jinhui⁵,Yao Jia¹,Yuan Liqin¹,Qian Ke¹,Zou Qiongyan¹,Yi Wenjun¹,Zhou Enxiang¹,Yang Kehu⁵

Affiliation:

1. Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, China

2. Department of Urology, The Second Hospital of Lanzhou University, Lanzhou, China

3. Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, China

4. Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases, Xijing Hospital, Four Military Medical University, Xi'an, Shaanxi, China

5. Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China

Abstract

Aim: To assess the prognostic values of Ki-67 in neoadjuvant setting for breast cancer patients. Methods: PubMed and EMBASE were searched. Revman software was used to conduct random-effect model meta-analysis. Results: 49 studies (14,076 patients) were included. High Ki-67 before and after neoadjuvant chemotherapy were associated with worse overall survival (OS; before: hazard ratio [HR]: 2.29; 95% CI: 1.42–3.69; after: HR: 2.24; 95% CI: 1.82–2.75) and disease-free survival (DFS; before: HR: 1.54; 95% CI: 1.23–1.95; after: HR: 2.08; 95% CI: 1.83–2.37). Low/no reduction or increase might be associated with worse DFS (HR: 2.13; 95% CI: 1.51–3.02) and OS. Conclusion: Ki-67 before and after neoadjuvant chemotherapy, as well as the change could predict the prognosis for breast cancer patients.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2016-0428

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