Risk factors for bone metastasis in completely resected non-small-cell lung cancer

Abstract

Aim: We assessed risk factors for bone metastasis in patients with completely resected non-small-cell lung cancer (NSCLC). Materials & methods: A total of 374 NSCLC patients who had undergone a complete resection from January 2008 to May 2012 were included in this retrospective study. The Kaplan–Meier method and multivariate Cox regression analysis were used to evaluate risk factors for bone metastasis. Results: A total of 47 (47/374; 12.6%) patients developed bone metastasis up until the last follow-up time. The patients with bone metastasis included 33 adenocarcinoma patients and 6 (4.9%) squamous cell carcinoma patients (p = 0.001). There were 17 (10.2%) patients with pathological stage (P-stage) I disease, 9 (9.5%) patients with P-stage II disease and 21 (18.8%) patients with P-stage III disease (p = 0.007) among all the bone metastasis patients. For patients without or with bone metastasis, the overall survival ratio at 3 years was 71.6% compared with 46.8% (p < 0.0001), respectively. Conclusion: Adenocarcinoma and P-stage III disease were related to a high risk of bone metastasis.