Alkaline phosphatase activity in human colostrum as a valuable predictive biomarker for lactational mastitis in nursing mothers-Reference-Cited by-同舟云学术

Alkaline phosphatase activity in human colostrum as a valuable predictive biomarker for lactational mastitis in nursing mothers

Published:2012-08 Issue:4 Volume:6 Page:553-558
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Bjelakovic Ljiljana¹,Kocic Gordana²,Bjelakovic Bojko³,Zivkovic Nikola⁴,Stojanović Dusica⁵,Sokolovic Danka⁶,Mladenovic-Ciric Ivana⁷,Sokolovic Dusan²

Affiliation:

1. Department of Hygiene, Faculty of Sport and Physical Education, University of Nis, Čarnojevića street 10 a 18000 Nis, Serbia.

2. Institute of Biochemistry, Medical Faculty, University of Nis, Serbia

3. Clinic of Pediatrics, Clinical Center, Nis, Serbia

4. Institute of Pathology, Medical Faculty, University of Nis, Serbia

5. Institute of Hygiene, Medical Faculty, University of Nis, Serbia

6. Institute of Transfusiology, Nis, Serbia

7. Department of Sport Medicine, Faculty of Sport and Physical Education, University of Nis, Serbia

Abstract

Aims: Biochemical investigations have shown that an indigenous milk enzyme – alkaline phosphatase (ALP) – which is detectable in the lactocytes, plays a very important diagnostic role in clinical medicine, since its activity varies in different tissues and serves as a specific indicator of disease states. The purpose of this study was to evaluate ALP activity in human colostrum as a possible early predictive biomarker for lactational mastitis in nursing mothers. Patients & methods: During a period from May to July 2010, a total of 60 healthy nursing mothers were recruited for this study. Results: The mean level of colostrum ALP activity from the affected breasts was significantly higher when compared with ALP activity from the contralateral asymptomatic as well as ‘healthy’ breasts (p < 0.01). Conclusion: Determining ALP activity in colostrum could be a valuable biochemical marker for an early prediction of mastitis in nursing mothers.

Publisher

Future Medicine Ltd

Subject

Biochemistry, medical,Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm.12.45

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