Nanotargeted agents: an emerging therapeutic strategy for breast cancer

Author:

Du Manling1,Ouyang Yong2,Meng Fansu3,Ma Qianqian1,Liu Hui1,Zhuang Yong1,Pang Mujuan1,Cai Tiange4,Cai Yu15

Affiliation:

1. College of Pharmacy, Jinan University, Guangzhou 510632, PR China

2. Guangzhou Hospital of Integrated Traditional Chinese & Western Medicine, Guangzhou 510800, PR China

3. Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of TCM, Zhongshan, Guangdong 528400, PR China

4. College of Life Sciences, Liaoning University, Shenyang 110036, PR China

5. Cancer Research Institute of Jinan University, Guangzhou 510632, PR China

Abstract

Breast cancer is the most common female cancer worldwide and represents 12% of all cancer cases. Improvements in survival rates are largely attributed to improved screening and diagnosis. Conventional chemotherapy remains an important treatment option but it is beset with poor cell selectivity, serious side effects and resistance. Nanoparticle drug delivery systems bring promising opportunities to breast cancer treatment. They may improve chemotherapy by targeting drugs to tumors, generating high drug concentrations at tumors providing slow release of the drug, increased drug stability and concomitant reductions in side effects. The nanotechnology-based drug delivery approaches and the current research and application status of nano-targeted agents for breast cancer are discussed in this review to provide a basis for further study on targeted drug delivery systems.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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