Gelatin tannate versus other antidiarrheal medication in children with acute gastroenteritis: a retrospective, observational study-Reference-Cited by-同舟云学术

Gelatin tannate versus other antidiarrheal medication in children with acute gastroenteritis: a retrospective, observational study

Published:2019-02 Issue:3 Volume:8 Page:187-194
ISSN:2042-6305
Container-title:Journal of Comparative Effectiveness Research
language:en
Short-container-title:Journal of Comparative Effectiveness Research

Author:

Serban Elena D¹,Manolache Mihai²

Affiliation:

1. 2nd Department of Pediatrics, ‘Iuliu Hatieganu’ University of Medicine & Pharmacy, Emergency Clinical Hospital for Children, Cluj-Napoca, Romania

2. Clinical Research & Regulatory Division, CEBIS International, Bucharest, Romania

Abstract

Aim: To evaluate the effectiveness and safety of gelatin tannate (GT) for acute gastroenteritis (AGE) in children. Materials & methods: In this retrospective, observational study, children admitted for AGE received GT ± oral rehydration solution (ORS; n = 46) or other antidiarrheal medications ± ORS (n = 46). Number and consistency of stools were recorded. Results: Children were aged 6 months to 7.9 years. GT ± ORS reduced diarrhea duration (29.0 vs 45.4 h, p < 0.0001) and normalized stool consistency at 72 h in significantly more patients (87.0 vs 30.4%; p = 0.026) compared with other antidiarrheal medications ± ORS. Differences in favor of GT were apparent from 12 h onward. Conclusion: GT is more effective than conventional treatment for managing AGE in children.

Publisher

Future Medicine Ltd

Subject

Health Policy

Link

https://www.futuremedicine.com/doi/pdf/10.2217/cer-2018-0082

Reference19 articles.

1. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases Evidence-Based Guidelines for the Management of Acute Gastroenteritis in Children in Europe

2. Universal Recommendations for the Management of Acute Diarrhea in Nonmalnourished Children

3. An international consensus report on a new algorithm for the management of infant diarrhoea

4. Acute Diarrhea in Adults and Children

5. Role of Antidiarrhoeal Drugs as Adjunctive Therapies for Acute Diarrhoea in Children

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